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작성일 : 15-01-30 12:21
연구단계 1단계 : 2년차
논문제목(영문) Cardioprotective effect of fimasartan, a new Angiotensin receptor blocker, in a porcine model of acute myocardial infarction.
국내외구분 국외 SCI여부 SCI
연구책임자역활 주저자 논문기여율 50%
주저자명 Sim DS
교신저자명 Jeong MH
공동저자명 Song HC, Kim J, Chong A, Bom HS, Jeong IS, Oh SG, Kim JM, Park DS, Kim JH, Lim KS, Ryu SH, Kim SH, Kim SS, Jang SY, Cho JY, Jeong HC, Lee KH, Park KH, Yoon NS, Yoon HJ, Kim KH, Hong YJ, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC
게제년월일 2015-01-01
ISSN 1011-8934
Impact Factor 1.253
학술지명 J Korean Med SCI
서지사항 0집 / 30권 / 1호,   페이지(34 - 43)
병기표기 단독
Acknowledgement
기재여부

※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정.
- 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)"
- 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project,
(HI13C1527) Ministry of Health & Welfare, Republic of Korea. "
요약초록문
(Abstract) 입력
Cardioprotective effect of fimasartan, a new angiotensin receptor blocker (ARB), was evaluated in a porcine model of acute myocardial infarction (MI). Fifty swine were randomized to group 1 (sham, n=10), group 2 (no angiotensin-converting enzyme inhibitor [ACEI] or ARB, n=10), group 3 (perindopril 2 mg daily, n=10), group 4 (valsartan 40 mg daily, n=10), or group 5 (fimasartan 30 mg daily, n=10). Acute MI was induced by occlusion of the left anterior descending artery for 50 min. Echocardiography, single photon emission computed tomography (SPECT), and F-18 fluorodeoxyglucose cardiac positron emission tomography (PET) were performed at baseline, 1 week, and 4 weeks. Iodine-123 meta-iodobenzylguanidine (MIBG) scan was done at 6 weeks for visualization of cardiac sympathetic activity. Left ventricular function and volumes at 4 weeks were similar between the 5 groups. No difference was observed in groups 2 to 5 in SPECT perfusion defect, matched and mismatched segments between SPECT and PET at 1 week and 4 weeks. MIBG scan showed similar uptake between the 5 groups. Pathologic analysis showed similar infarct size in groups 2 to 5. Infarct size reduction was not observed with use of fimasartan as well as other ACEI and ARB in a porcine model of acute MI.

 
Total 26
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25 Impact of renal function on changes of plaque char… Hong YJ Jeong MH Int J Cardiol
24 Reliable femoral chronic total occlusion model usi… Kim NY, Lim KS Jeong MH J Mater Sci Mater Med
23 Cardioprotective effect of fimasartan, a new Angio… Sim DS Jeong MH J Korean Med SCI
22 Clinical significance of chronic kidney disease an… Hwang HS Ahn Y Am J Nephrol
21 Impact of postdischarge statin withdrawal on long-… Kim MC Ahn Y Am J Cardiol
20 Impact of low level of high-density lipoprotein-ch… JI MS Jeong MH J Cardiol
19 In vivo evaluation and characterization of a bio-a… Park SA Jeong MH, Park JK Materials Letters
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17 Current Trend of Acute Myocardial Infarction in Ko… Kook HY Jeong MH Am J Cardiol
16 Gallic acid inhibits vascular calcification throug… Kee HJ Jeong MH Vascul Pharmacol
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