작성일 : 14-12-05 12:37
| 연구단계 | 1단계 : 2년차 | ||
| 논문제목(영문) | Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway. | ||
| 국내외구분 | 국외 | SCI여부 | SCI |
| 연구책임자역활 | 교신저자 | 논문기여율 | 30% |
| 주저자명 | Kee HJ | ||
| 교신저자명 | Jeong MH | ||
| 공동저자명 | Cho SN, Kim GR, Choi SY, Ryu Y, Kim IK, Hong YJ, Park HW, Ahn Y, Cho JG, Park JC | ||
| 게제년월일 | 2014-11-01 | ||
| ISSN | 1537-1891 | ||
| Impact Factor | 4.620 | ||
| 학술지명 | Vascul Pharmacol | ||
| 서지사항 | 0집 / 63권 / 2호, 페이지(71 - 78) | ||
| 병기표기 | 단독 | ||
| Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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| 요약초록문 (Abstract) 입력 |
Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism. Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway. | ||
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