작성일 : 14-11-06 09:31
| 연구단계 | 1단계 :1년차 | ||
| 논문제목(영문) | Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways. | ||
| 국내외구분 | 국외 | SCI여부 | SCI |
| 연구책임자역활 | 교신저자 | 논문기여율 | 30% |
| 주저자명 | Kee HJ | ||
| 교신저자명 | Jeong MH | ||
| 공동저자명 | Kim GR, Kim IK | ||
| 게제년월일 | 2014-10-21 | ||
| ISSN | 1613-4125 | ||
| Impact Factor | 4.909 | ||
| 학술지명 | Mol Nutr Food Res | ||
| 서지사항 | 0집 / 0권 / 0호, 페이지(Epub - 0) | ||
| 병기표기 | 단독 | ||
| Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
||
| 요약초록문 (Abstract) 입력 |
SCOPE:: Sulforaphane is a naturally occurring isothiocynate compound found in cruciferous vegetables. Here we report the effect of sulforaphane on cardiac hypertrophy and propose an underlying mechanism. METHODS AND RESULTS:: Sulforaphane suppresses cardiomyocyte hypertrophy induced by hypertrophic stimuli in vitro and in vivo. Sulforaphane suppresses the expressions of fetal genes, including ANP, BNP, and β-MHC. We used an siRNA technique and ANP promoter with mutated GATA binding sites to demonstrate that sulforaphane mediates cardiac hypertrophy by modulating transcription factors GATA4/6. CONCLUSION:: These results suggest that sulforaphane has the potential to prevent cardiac hypertrophy by down-regulating GATA4/6 and MAPK signaling pathways. This article is protected by copyright. All rights reserved. |
||
Total 26
|
