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작성일 : 14-09-21 12:36
연구단계 1단계 :1년차
논문제목(영문) Trichostatin A enhances osteogenic differentiation through activation of ERK pathways in mouse bone marrow multipotent stromal cells
국내외구분 국외 SCI여부 SCI
연구책임자역활 교신저자 논문기여율 30%
주저자명 Park DS
교신저자명 Yoon TR
공동저자명 Kim HK, Park KS
게제년월일 2014-04-01
ISSN 1738-2696
Impact Factor 0.613
학술지명 Tissue Engineering and Regenerative Medicine
서지사항 0집 / 11권 / 2호,   페이지(131 - 136)
병기표기 단독
Acknowledgement
기재여부

※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정.
- 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)"
- 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project,
(HI13C1527) Ministry of Health & Welfare, Republic of Korea. "
요약초록문
(Abstract) 입력
Trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, is a potentially important anticancer agent. TSA has been extensively studied for inducing various malignancies concerning growth inhibition, cell cycle arrest, and apoptosis. TSA reportedly modulates the expression of several genes by inhibiting the activity of HDACs, including genes involved in cell differentiation and proliferation. The present study investigated osteoblastic differentiation concerning the mechanism of TSA in D1 multipotent mouse bone marrow stromal cells. D1 cells were cultured in osteogenic differentiation medium (ODM) for 6 days, treated with TSA for 1 day and then analyzed for viability, alkaline phosphatase (ALP) activity, Ca++ bone marrow stromal cells (alizarin red S staining), gene expression (reverse transcriptase-polymerase chain reaction) and protein production (Western blotting). TSA promoted ALP protein production. TSA induced formation of mineralized nodules in bone marrow stromal cells. Western blotting showed that TSA activated phosphorylation of extracellular signal-regulated kinase 1/2 in D1 cells. These findings indicate that TSA triggers osteoblast differentiation by activation of the extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling pathway and via the expression of ALP activity in osteoblasts. TSA may be a promising target that could be developed for supplementation of osteoporotic diseases.

 
Total 48
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